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Percutaneous Coronary Intervention PCI Procedure Indications Steps Complications Management

Author: Medical Editorial Team – Board-certified physicians with 10+ years in emergency medicine. Learn more.

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Frequently Asked Questions

What is Percutaneous Coronary Intervention (PCI)?

Percutaneous Coronary Intervention is a minimally invasive catheter-based procedure used to restore blood flow in narrowed or occluded coronary arteries, usually by balloon angioplasty followed by stent implantation.

What are the main indications for PCI?

PCI is indicated in ST-elevation myocardial infarction (primary PCI), high-risk NSTEMI or unstable angina, chronic stable angina with significant ischemia, and selected cases of left main or proximal LAD disease.

What is primary PCI?

Primary PCI refers to immediate PCI performed as the first reperfusion strategy in acute STEMI, ideally within 90–120 minutes of first medical contact.

What is the difference between PCI and coronary angioplasty?

Coronary angioplasty refers only to balloon dilatation of a coronary artery, whereas PCI includes angioplasty plus stent implantation and adjunctive pharmacotherapy.

What are drug-eluting stents (DES)?

Drug-eluting stents are coronary stents coated with antiproliferative drugs that inhibit neointimal hyperplasia, thereby reducing the risk of in-stent restenosis.

Why are drug-eluting stents preferred over bare-metal stents?

Drug-eluting stents significantly reduce restenosis rates compared to bare-metal stents, making them the standard of care in most PCI procedures.

What is dual antiplatelet therapy (DAPT)?

Dual antiplatelet therapy consists of aspirin plus a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) to prevent stent thrombosis after PCI.

How long should DAPT be continued after PCI?

After PCI with drug-eluting stents, DAPT is recommended for at least 12 months in acute coronary syndrome and at least 6 months in stable coronary artery disease, unless bleeding risk is high.

What are the common access routes for PCI?

The common access routes for PCI are the radial artery and femoral artery, with radial access preferred due to lower bleeding complications.

What is the no-reflow phenomenon in PCI?

No-reflow is a complication where there is inadequate myocardial perfusion despite successful opening of the epicardial coronary artery, usually due to microvascular obstruction.

What are the major complications of PCI?

Major complications include stent thrombosis, coronary dissection or perforation, no-reflow phenomenon, contrast-induced nephropathy, bleeding, and vascular access complications.

What is contrast-induced nephropathy after PCI?

Contrast-induced nephropathy is acute kidney injury occurring after exposure to contrast media during PCI, characterized by a rise in serum creatinine within 48–72 hours.

When is CABG preferred over PCI?

CABG is preferred in patients with diabetes and multivessel disease, left main disease with high SYNTAX score, and complex coronary anatomy unsuitable for PCI.

What is in-stent restenosis?

In-stent restenosis is re-narrowing of a stented coronary segment due to neointimal hyperplasia, typically occurring months after PCI.

What is the most feared late complication of PCI?

Late stent thrombosis is the most feared late complication of PCI because it can lead to sudden myocardial infarction and death.

MCQ Test - Percutaneous Coronary Intervention PCI Procedure Indications Steps Complications Management

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1 A 54-year-old man presents within 60 minutes of severe chest pain. ECG shows inferior STEMI. A PCI-capable center is available. What is the most appropriate reperfusion strategy?

Explanation:

Primary PCI is the preferred reperfusion strategy in STEMI when it can be performed within guideline-recommended time limits.

2 A patient with NSTEMI has recurrent chest pain, dynamic ST-segment depression, and elevated troponin levels despite medical therapy. What is the best next step?

Explanation:

High-risk NSTEMI patients benefit from an early invasive approach with coronary angiography and PCI.

3 Soon after PCI with drug-eluting stent implantation, a patient develops sudden chest pain, hypotension, and ST elevation in the same territory. What is the most likely diagnosis?

Explanation:

Acute stent thrombosis presents with sudden ischemia and hemodynamic compromise shortly after PCI.

4 A diabetic patient with triple-vessel coronary artery disease and reduced left ventricular ejection fraction is evaluated for revascularization. Which strategy provides the best long-term survival?

Explanation:

CABG provides superior survival benefit in diabetics with multivessel coronary artery disease.

5 During PCI for an acute myocardial infarction, the epicardial artery is opened but there is persistent poor myocardial perfusion distally. What is this complication called?

Explanation:

No-reflow results from microvascular obstruction despite successful epicardial artery opening.

6 A patient develops a rise in serum creatinine 48 hours after coronary angiography and PCI. Urine output is adequate and there is no hypotension. What is the most likely cause?

Explanation:

Contrast-induced nephropathy is a common complication after PCI, presenting with delayed creatinine rise.

7 A patient undergoing PCI develops a sudden fall in platelet count with new thrombosis 24 hours after exposure to heparin. What is the most likely diagnosis?

Explanation:

Heparin-induced thrombocytopenia causes paradoxical thrombosis with thrombocytopenia after heparin exposure.

8 Radial artery access is preferred over femoral access for PCI primarily because it reduces which complication?

Explanation:

Radial access significantly reduces bleeding and vascular complications compared to femoral access.

9 A patient stops dual antiplatelet therapy one week after drug-eluting stent implantation. What is the most serious consequence?

Explanation:

Premature discontinuation of DAPT is the strongest risk factor for stent thrombosis.

10 During PCI, the patient develops hypotension with elevated jugular venous pressure and muffled heart sounds. What is the most likely cause?

Explanation:

Coronary perforation can cause hemopericardium leading to acute cardiac tamponade.

11 A patient with stable angina undergoes elective PCI with a drug-eluting stent. What is the minimum recommended duration of dual antiplatelet therapy if bleeding risk is low?

Explanation:

In stable coronary artery disease, at least 6 months of DAPT is recommended after DES implantation.

12 A patient undergoing primary PCI develops ventricular fibrillation during balloon inflation. What is the most likely mechanism?

Explanation:

Transient coronary occlusion during balloon inflation can precipitate ventricular arrhythmias.

13 A patient develops chest pain weeks after PCI. Angiography shows narrowing within the stent due to tissue growth. What is the diagnosis?

Explanation:

In-stent restenosis is caused by neointimal hyperplasia leading to gradual luminal narrowing.

14 A patient with STEMI arrives late (14 hours after symptom onset) but still has ongoing chest pain and ST elevation. What is the best management?

Explanation:

Primary PCI is indicated even in late presenters if there is ongoing ischemia or hemodynamic instability.

15 A patient with left main coronary artery disease and high SYNTAX score is being evaluated. What is the preferred revascularization strategy?

Explanation:

CABG is preferred in left main disease with high anatomical complexity (high SYNTAX score).

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