Electrocardiogram ECG Interpretation Guide for Medical and Clinical Practice
medicine

Electrocardiogram ECG Interpretation Guide for Medical and Clinical Practice


Electrocardiogram (ECG)

Definition

An Electrocardiogram (ECG) is a non-invasive diagnostic test that records the electrical activity of the heart over time using surface electrodes placed on the body. It reflects depolarization and repolarization of atrial and ventricular myocardium.

Key external reference:

https://radiopaedia.org/articles/electrocardiogram

https://www.ecgpedia.org/wiki/Main_Page


Indications

  • Chest pain / suspected acute coronary syndrome
  • Palpitations, syncope, presyncope
  • Arrhythmia detection and monitoring
  • Electrolyte abnormalities
  • Drug toxicity (digoxin, antiarrhythmics)
  • Structural heart disease screening
  • Pre-operative assessment

ECG Leads and Views

Standard 12-Lead ECG

Limb Leads

  • Lead I, II, III (Bipolar)
  • aVR, aVL, aVF (Augmented unipolar)

Chest (Precordial) Leads

  • V1–V6

Anatomical Correlation

| Leads | Area of Heart |

| ------------- | ----------------- |

| II, III, aVF | Inferior wall |

| I, aVL, V5–V6 | Lateral wall |

| V1–V4 | Anterior / Septal |

| V7–V9 | Posterior wall |

| V3R–V4R | Right ventricle |

Reference:

https://litfl.com/ecg-lead-positioning/


ECG Paper and Calibration

  • Speed: 25 mm/sec
  • Voltage: 10 mm = 1 mV
  • 1 small square = 0.04 sec
  • 1 large square = 0.20 sec

Normal ECG Waves and Intervals

P Wave

  • Atrial depolarization
  • Duration: <120 ms
  • Height: <2.5 mm (lead II)

Abnormalities:

  • Tall P → Right atrial enlargement
  • Broad/notched P → Left atrial enlargement

Reference:

https://www.ecgpedia.org/wiki/P_wave


PR Interval

  • AV nodal conduction
  • Normal: 120–200 ms

Abnormal:

  • Short PR → WPW syndrome
  • Prolonged PR → First-degree AV block

QRS Complex

  • Ventricular depolarization
  • Normal duration: <120 ms

Wide QRS causes:

  • Bundle branch block
  • Ventricular rhythm
  • Hyperkalemia
  • Drug toxicity

ST Segment

  • Normally isoelectric
  • Elevation or depression indicates ischemia or injury

Reference:

https://litfl.com/st-segment-ecg-library/


T Wave

  • Ventricular repolarization
  • Inversion indicates ischemia, strain, CNS pathology

QT Interval

  • Total ventricular depolarization + repolarization
  • QTc (Bazett formula):

`

QTc = QT / √RR

`

Normal QTc:

  • Male: <440 ms
  • Female: <460 ms

Prolonged QT → risk of Torsades de Pointes

Reference:

https://litfl.com/qt-interval-ecg-library/


Systematic ECG Interpretation (STEPWISE)

1. Rate

  • Regular rhythm: 300 ÷ large squares
  • Irregular rhythm: count QRS in 10 sec × 6

2. Rhythm

  • Sinus rhythm: P before every QRS, upright P in II
  • Irregularly irregular → Atrial fibrillation

3. Axis

  • Normal: −30° to +90°
  • Left axis deviation → LBBB, LVH
  • Right axis deviation → RBBB, PE

Reference:

https://litfl.com/ecg-axis-interpretation/


4. Intervals

  • PR, QRS, QTc evaluation

5. Hypertrophy Patterns

Left Ventricular Hypertrophy

  • S(V1) + R(V5/V6) > 35 mm

Right Ventricular Hypertrophy

  • R/S > 1 in V1

6. Ischemia and Infarction

STEMI Criteria

  • ST elevation ≥1 mm in ≥2 contiguous leads
  • New LBBB with symptoms

NSTEMI

  • ST depression, T inversion, positive troponin

Reference:

https://www.escardio.org/Guidelines


Common ECG Arrhythmias

Atrial Fibrillation

  • No P waves
  • Irregularly irregular rhythm

Atrial Flutter

  • Saw-tooth flutter waves
  • Ventricular rate often 150 bpm

Ventricular Tachycardia

  • Wide QRS tachycardia
  • AV dissociation

Ventricular Fibrillation

  • Chaotic waveform
  • Cardiac arrest rhythm

Reference:

https://litfl.com/ecg-library/


ECG in Electrolyte Abnormalities

| Electrolyte | ECG Changes |

| ------------- | ---------------------------------- |

| Hyperkalemia | Tall tented T, wide QRS, sine wave |

| Hypokalemia | U waves, flat T |

| Hypercalcemia | Short QT |

| Hypocalcemia | Prolonged QT |

Reference:

https://radiopaedia.org/articles/electrolyte-disturbances-on-ecg


ECG in Drug Toxicity

Digoxin

  • Scooped ST depression
  • Atrial tachycardia with block

Tricyclic Antidepressants

  • Wide QRS
  • Right axis deviation

Special ECG Patterns

  • Brugada syndrome: Coved ST elevation V1–V3
  • WPW: Short PR, delta wave
  • Pericarditis: Diffuse ST elevation, PR depression
  • Pulmonary embolism: S1Q3T3 pattern

Reference:

https://radiopaedia.org/articles/brugada-syndrome


Limitations of ECG

  • Can be normal in early ischemia
  • Poor sensitivity for posterior MI without additional leads
  • Electrical activity does not always equal mechanical function

Interactive MCQ Quiz

MCQ Exam Mode

15 Questions
Question 1 of 15

Frequently Asked Questions

An electrocardiogram (ECG) is a non-invasive test that records the electrical activity of the heart over time to assess heart rhythm, rate, conduction abnormalities, ischemia, and structural heart disease.
A normal ECG shows sinus rhythm with a rate of 60–100 bpm, normal P waves before each QRS complex, PR interval 120–200 ms, QRS duration <120 ms, and no significant ST-T abnormalities.
The main components are the P wave (atrial depolarization), PR interval (AV conduction), QRS complex (ventricular depolarization), ST segment, T wave (ventricular repolarization), and QT interval.
A standard ECG uses 12 leads: 6 limb leads (I, II, III, aVR, aVL, aVF) and 6 precordial chest leads (V1–V6).
ST elevation usually indicates acute myocardial injury, most commonly ST-elevation myocardial infarction (STEMI), but can also be seen in pericarditis, early repolarization, and ventricular aneurysm.
Typical changes include hyperacute T waves, ST elevation or depression, pathological Q waves, and T wave inversion depending on the stage and location of infarction.
Prolonged QT interval increases the risk of torsades de pointes, a potentially life-threatening polymorphic ventricular tachycardia.
In regular rhythm, heart rate is calculated as 300 divided by the number of large squares between two R waves. In irregular rhythm, QRS complexes are counted in 10 seconds and multiplied by 6.
Atrial fibrillation shows an irregularly irregular rhythm with absent P waves and variable R–R intervals.
A wide QRS complex (>120 ms) suggests abnormal ventricular conduction such as bundle branch block, ventricular rhythm, hyperkalemia, or drug toxicity.
Hyperkalemia causes tall peaked T waves and wide QRS, hypokalemia causes U waves and flat T waves, hypercalcemia shortens QT interval, and hypocalcemia prolongs QT interval.
Axis deviation refers to abnormal direction of ventricular depolarization. Left axis deviation and right axis deviation are associated with specific cardiac and pulmonary conditions.
Acute pericarditis typically shows diffuse ST elevation with PR segment depression across multiple leads.
Yes, ECG can be normal in early ischemia, stable angina, or some structural heart diseases, so clinical correlation is always required.
ECG provides rapid diagnosis of life-threatening conditions such as myocardial infarction, ventricular arrhythmias, heart block, and electrolyte disturbances, guiding immediate management.